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1

Intracellular localization of pregnane X receptor in HepG2 cells cultured by the hanging drop method

Yokobori, Kosuke, Kobayashi, Kaoru, Azuma, Ikuko, Akita, Hidetaka, Chiba, Kan

Journal:

Drug Metabolism and Pharmacokinetics

Year:

2017

Language:

english

File:

PDF, 1.88 MB

english, 2017

2

A Novel Variant Allele of OATP-C (SLCO1B1) Found in a Japanese Patient with Pravastatin-induced Myopathy

Morimoto, Kaori, Oishi, Tomoharu, Ueda, Shiro, Ueda, Madoka, Hosokawa, Masakiyo, Chiba, Kan

Journal:

Drug Metabolism and Pharmacokinetics

Year:

2004

Language:

english

File:

PDF, 213 KB

english, 2004

3

Effect of Pregnenolone 16α-Carbonitrile on the Expression of P-Glycoprotein in the Intestine, Brain and Liver of Mice

Yamasaki, Yuki, Kobayashi, Kaoru, Chiba, Kan

Journal:

Biological & Pharmaceutical Bulletin

Year:

2018

Language:

english

File:

PDF, 863 KB

english, 2018

4

Sox21 Regulates Anapc10 Expression and Determines the Fate of Ectodermal Organ

Saito, Kan, Michon, Frederic, Yamada, Aya, Inuzuka, Hiroyuki, Yamaguchi, Satoko, Fukumoto, Emiko, Yoshizaki, Keigo, Nakamura, Takashi, Arakaki, Makiko, Chiba, Yuta, Ishikawa, Masaki, Okano, Hideyuki,

Journal:

Year:

2020

File:

PDF, 9.92 MB

2020

5

Metabolism of the neurotoxic tertiary amine, MPTP, by brain monoamine oxidase

Kan Chiba, Anthony Trevor, Neal Castagnoli Jr.

Journal:

Biochemical and Biophysical Research Communications

Year:

1984

Language:

english

File:

PDF, 330 KB

english, 1984

6

Prediction of in vivo drug metabolism in the human liver from in vitro metabolism data

Takafumi Iwatsubo, Noriko Hirota, Tsuyoshi Ooie, Hiroshi Suzuki, Noriaki Shimada, Kan Chiba, Takashi Ishizaki, Carol E. Green, Charles A. Tyson, Yuichi Sugiyama

Journal:

Pharmacology & Therapeutics

Year:

1997

Language:

english

File:

PDF, 2.66 MB

english, 1997

7

Identification of CYP isozymes involved in benzbromarone metabolism in human liver microsomes

Kaoru Kobayashi, Eri Kajiwara, Masayuki Ishikawa, Hidenobu Oka, Kan Chiba

Journal:

Biopharmaceutics & Drug Disposition

Year:

2012

Language:

english

File:

PDF, 170 KB

english, 2012

8

Effects of N-methylmercaptoimidazole on the disposition of MPTP and its metabolites in mice

Kan Chiba, Hidekazu Horii, Emi Kubota, Takashi Ishizaki, Yuriko Kato

Journal:

European Journal of Pharmacology

Year:

1990

Language:

english

File:

PDF, 631 KB

english, 1990

9

Acrolein stimulates the synthesis of IL-6 and C-reactive protein (CRP) in thrombosis model mice and cultured cells

Saiki, Ryotaro, Hayashi, Daisuke, Ikuo, Yukiko, Nishimura, Kazuhiro, Ishii, Itsuko, Kobayashi, Kaoru, Chiba, Kan, Toida, Toshihiko, Kashiwagi, Keiko, Igarashi, Kazuei

Journal:

Journal of Neurochemistry

Year:

2013

Language:

english

File:

PDF, 530 KB

english, 2013

10

Enhanced Immunostimulating Activity of Lactobacilli-Mimicking Materials by Controlling Size

Nagahama, Koji, Kumano, Takayuki, Nakagawa, Yuichi, Oyama, Naho, Tsuji, Hirokazu, Moriyama, Kaoru, Shida, Kan, Nomoto, Koji, Chiba, Katsuyoshi, Koumoto, Kazuya, Matsui, Jun

Journal:

Bioconjugate Chemistry

Year:

2015

Language:

english

File:

PDF, 1.50 MB

english, 2015

11

Evaluation of the drug-mediated induction of metabolic enzymes using a novel CYP3A/PXR humanized mouse to predict intestinal pharmacokinetics

Satoh, Daisuke, Kobayashi, Kaoru, Kuze, Jiro, Yamamoto, Takushi, Igarashi, Katsuhide, Kitajima, Satoshi, Kanno, Jun, Chiba, Kan, Osaki, Mitshuhiko, Oshimura, Mitsuo, Yasuhiro, Kazuki

Journal:

Drug Metabolism and Pharmacokinetics

Year:

2018

Language:

english

File:

PDF, 51 KB

english, 2018

12

Automated high-performance liquid chromatographic method for the determination of antipyrine and its metabolites in urine : Some preliminary results obtained from smokers and non-smokers

Akihiko Nakagawa, Kan-ichi Nakamura, Takashi Ishizaki, Kan Chiba

Journal:

Journal of Chromatography B: Biomedical Sciences and Applications

Year:

1982

Language:

english

File:

PDF, 826 KB

english, 1982

13

Effects of genetic defects in the CYP2C19 gene on the N-demethylation of imipramine, and clinical outcome of imipramine therapy

SHIGERU MORINOBU, TAKESHI TANAKA, SHINOBU KAWAKATSU, SHIRO TOTSUKA, ERIKO KOYAMA, KAN CHIBA, TAKASHI ISHIZAKI, TAKAHIRO KUBOTA

Journal:

Psychiatry and Clinical Neurosciences

Year:

1997

Language:

english

File:

PDF, 516 KB

english, 1997

14

Dexamethasone-mediated transcriptional regulation of rat carboxylesterase 2 gene

Hori, Takeshi, Jin, Liangjing, Fujii, Ayako, Furihata, Tomomi, Nagahara, Yuko, Chiba, Kan, Hosokawa, Masakiyo

Journal:

Year:

2012

Language:

english

File:

PDF, 1010 KB

english, 2012

15

Surgical Results and Related Factors for Ossification of Posterior Longitudinal Ligament of the Thoracic Spine

Matsumoto, Morio, Chiba, Kazuhiro, Toyama, Yoshiaki, Takeshita, Katsushi, Seichi, Atsushi, Nakamura, Kozo, Arimizu, Jun, Fujibayashi, Shunsuke, Hirabayashi, Shigeru, Hirano, Toru, Iwasaki, Motoki, Kan

Journal:

Year:

2008

Language:

english

File:

PDF, 542 KB

english, 2008

16

Identification of Primary Equilibrative Nucleoside Transporter 1 mRNA Isoforms Resulting from Alternative Promoter Usage in Human Hepatocytes

Furihata, Tomomi, Mizuguchi, Misa, Suzuki, Yuki, Matsumoto, Shogo, Kobayashi, Kaoru, Chiba, Kan

Journal:

Drug Metabolism and Pharmacokinetics

Year:

2014

Language:

english

File:

PDF, 1.38 MB

english, 2014

17

Cytotoxic Effects of Benzbromarone and Its 1′-Hydroxy Metabolite in Human Hepatocarcinoma FLC4 Cells Cultured on Micro-space Cell Culture Plates

Kobayashi, Kaoru, Kajiwara, Eri, Ishikawa, Masayuki, Mimura, Hanaka, Oka, Hidenobu, Ejiri, Yoko, Hosoda, Masaya, Chiba, Kan

Journal:

Drug Metabolism and Pharmacokinetics

Year:

2013

Language:

english

File:

PDF, 367 KB

english, 2013

18

Single-Cell RNA-Sequencing From Mouse Incisor Reveals Dental Epithelial Cell-Type Specific Genes

Chiba, Yuta, Saito, Kan, Martin, Daniel, Boger, Erich T., Rhodes, Craig, Yoshizaki, Keigo, Nakamura, Takashi, Yamada, Aya, Morell, Robert J., Yamada, Yoshihiko, Fukumoto, Satoshi

Journal:

Frontiers in Cell and Developmental Biology

Year:

2020

File:

PDF, 4.96 MB

2020

19

Mechanism of the decrease in catalytic activity of human cytochrome P450 2C9 polymorphic variants investigated by computational analysis

Eri Sano, Weihua Li, Hitomi Yuki, Xinli Liu, Tomomi Furihata, Kaoru Kobayashi, Kan Chiba, Saburo Neya, Tyuji Hoshino

Journal:

Journal of Computational Chemistry

Year:

2010

Language:

english

File:

PDF, 539 KB

english, 2010

20

CYP2C9 Ile359 and Leu359 variants: enzyme kinetic study with seven substrates

Takanashi, Kenji, Tainaka, Hitoshi, Kobayashi, Kaoru, Yasumori, Toshio, Hosakawa, Masakiyo, Chiba, Kan

Journal:

Pharmacogenetics

Year:

2000

Language:

english

File:

PDF, 266 KB

english, 2000

21

Comparison of human cytochrome P450 (CYP) isoforms involved in metabolism of SSRIs

Kobayashi, Kaoru, Ishizuka, Tomoko, Yamamoto, Tessai, Shimada, Noriaki, Yoshimura, Yoshitaka, Kamijima, Kunitoshi, Chiba, Kan

Journal:

International Clinical Psychopharmacology

Year:

2001

Language:

english

File:

PDF, 130 KB

english, 2001

22

The Effects of Neuroleptics (Haloperidol and Chlorpromazine) on the Pharmacokinetics of Valproic Acid in Schizophrenic Patients

ISHIZAKI, TAKASHI, CHIBA, KAN, SAITO, MIKIRO, KOBAYASHI, KAZUNARI, IIZUKA, REIJI

Journal:

Journal of Clinical Psychopharmacology

Year:

1984

File:

PDF, 734 KB

1984

23

Frequencies of the defective CYP2C19 alleles responsible for the mephenytoin poor metabolizer phenotype in various Oriental, Caucasian, Saudi Arabian and American black populations

Goldstein, Joyce A., Ishizaki, Takashi, Chiba, Kan, de Morais, Sonia M.F., Bell, Douglas, Krahn, Peter M., Price Evans, David A.

Journal:

Pharmacogenetics

Year:

1997

File:

PDF, 529 KB

1997

24

Human organic anion transporter 2 is an entecavir, but not tenofovir, transporter

Furihata, Tomomi, Morio, Hanae, Zhu, Meiyan, Suzuki, Yuki, Ide, Hideyuki, Tsubota, Akihito, Fu, Zhongguo, Anzai, Naohiko, Chiba, Kan

Journal:

Drug Metabolism and Pharmacokinetics

Year:

2016

Language:

english

File:

PDF, 665 KB

english, 2016

25

Expression Patterns of Claudin Family Members During Tooth Development and the Role of Claudin-10 (Cldn10) in Cytodifferentiation of Stratum Intermedium

Wang, Xin, Chiba, Yuta, Jia, Lingling, Yoshizaki, Keigo, Saito, Kan, Yamada, Aya, Qin, Man, Fukumoto, Satoshi

Journal:

Frontiers in Cell and Developmental Biology

Year:

2020

File:

PDF, 2.75 MB

2020

26

Effects of clarithromycin on the metabolism of omeprazole in relation to CYP2C19 genotype status in humans*

Furuta, Takahisa, Ohashi, Kyoichi, Kobayashi, Kaoru, Iida, Izumi, Yoshida, Hideo, Shirai, Naohito, Takashima, Misako, Kosuge, Kazuhiro, Hanai, Hiroyuki, Chiba, Kan, Ishizaki, Takashi, Kaneko, Eizo

Journal:

Clinical Pharmacology & Therapeutics

Year:

1999

Language:

english

File:

PDF, 155 KB

english, 1999

27

Reply

Kan Chiba, Takashi Ishizaki

Journal:

The Journal of Pediatrics

Year:

1981

Language:

english

File:

PDF, 193 KB

english, 1981

28

Characterization of release profile of ornithine carbamoyltransferase from primary rat hepatocytes treated with hepatotoxic drugs: Implications for its unique potential as a drug-induced liver injury biomarker

Furihata, Tomomi, Aizawa, Takayuki, Koibuchi, Akira, Zhu, Meiyan, Yamasaki, Yuki, Shibuya, Minaka, Chiba, Kan

Journal:

Drug Metabolism and Pharmacokinetics

Year:

2016

Language:

english

File:

PDF, 490 KB

english, 2016

29

Functional Analysis of Purine Nucleoside Phosphorylase as a Key Enzyme in Ribavirin Metabolism

Furihata, Tomomi, Kishida, Satoshi, Sugiura, Hanae, Kamiichi, Atsuko, Iikura, Minami, Chiba, Kan

Journal:

Drug Metabolism and Pharmacokinetics

Year:

2014

Language:

english

File:

PDF, 736 KB

english, 2014

30

Genetic Marker of Statin-induced Rhabdomyolysis

CHIBA, Kan, MORIMOTO, Kaori

Journal:

YAKUGAKU ZASSHI

Year:

2011

File:

PDF, 325 KB

2011

31

Perspective of Humanized Mouse Models for Assessing PK/PD and Toxic Profile of Drug Candidates in Preclinical Study

Journal:

Drug Metabolism and Pharmacokinetics

Year:

2014

Language:

english

File:

PDF, 56 KB

english, 2014

32

CYP3A4 inducible model for in vitro analysis of human drug metabolism using a bioartificial liver

Tohru Iwahori, Tomokazu Matsuura, Haruka Maehashi, Ken Sugo, Masaya Saito, Masakiyo Hosokawa, Kan Chiba, Takahiro Masaki, Hideki Aizaki, Kiyoshi Ohkawa, Tetsuro Suzuki

Journal:

Year:

2003

Language:

english

File:

PDF, 343 KB

english, 2003

33

Enhancement by cyanide of aniline p-hydroxylation activity in rat liver microsomes

Kamataki Tetsuya, Kitada Mitsukazu, Chiba Kan, Kitagawa Haruo, Imai Yoshio, Sato Ryo

Journal:

Biochemical Pharmacology

Year:

1980

Language:

english

File:

PDF, 788 KB

english, 1980

34

Metabolism of the nigrostriatal toxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine by liver homogenate fractions

Weissman, Jeff, Trevor, Anthony, Chiba, Kan, Peterson, Lisa A., Caldera, Patricia, Castagnoli, Neal, Baillie, Thomas

Journal:

Journal of Medicinal Chemistry

Year:

1985

Language:

english

File:

PDF, 720 KB

english, 1985

35

Structure–activity relationship study on α1 adrenergic receptor antagonists from beer

Toshiyuki Wakimoto, Makoto Nitta, Kana Kasahara, Taketo Chiba, Ye Yiping, Kuniro Tsuji, Toshiyuki Kan, Haruo Nukaya, Masaji Ishiguro, Minako Koike, Yoshiaki Yokoo, Yoshihide Suwa

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2009

Language:

english

File:

PDF, 348 KB

english, 2009

36

Functional analysis of a mutation in the SLCO1B1 gene (c.1628T>G) identified in a Japanese patient with pravastatin-induced myopathy

Furihata, Tomomi, Satoh, Naoki, Ohishi, Tomoharu, Ugajin, Miyuki, Kameyama, Yoshio, Morimoto, Kaori, Matsumoto, Sayaka, Yamashita, Keiko, Kobayashi, Kaoru, Chiba, Kan

Journal:

The Pharmacogenomics Journal

Year:

2009

Language:

english

File:

PDF, 215 KB

english, 2009

37

Observation of Clinically Relevant Drug Interaction in Chimeric Mice with Humanized Livers: The Case of Valproic Acid and Carbapenem Antibiotics

Suzuki, Eiko, Koyama, Kumiko, Nakai, Daisuke, Goda, Ryoya, Kuga, Hiroshi, Chiba, Kan

Journal:

European Journal of Drug Metabolism and Pharmacokinetics

Year:

2017

Language:

english

File:

PDF, 472 KB

english, 2017

38

Species Differences in Mechanism-Based Inactivation of CYP3A in Humans, Rats and Mice

Aueviriyavit, Sasitorn, Kobayashi, Kaoru, Chiba, Kan

Journal:

Drug Metabolism and Pharmacokinetics

Year:

2010

Language:

english

File:

PDF, 575 KB

english, 2010

39

Involvement of Hepatocyte Nuclear Factor 4alpha in Transcriptional Regulation of the Human Pregnane X Receptor Gene in the Human Liver

Iwazaki, Norihiko, Kobayashi, Kaoru, Morimoto, Kaori, Hirano, Mai, Kawashima, Sachiyo, Furihata, Tomomi, Chiba, Kan

Journal:

Drug Metabolism and Pharmacokinetics

Year:

2008

Language:

english

File:

PDF, 539 KB

english, 2008

40

Disposition kinetics and dynamics of nicainoprol, a new antiarrhythmic agent, in humans

Ishizaki, Takashi, Horai, Yukio, Kubota, Kiyoshi, Minegishi, Akemi, Echizen, Hirotoshi, Chiba, Kan

Journal:

Clinical Pharmacology & Therapeutics

Year:

1987

Language:

english

File:

PDF, 832 KB

english, 1987

41

Metabolism of medroxyprogesterone acetate (MPA) via CYP enzymes in vitro and effect of MPA on bleeding time in female rats in dependence on CYP activity in vivo

Nobuhito Mimura, Kaoru Kobayashi, Yoshika Nakamura, Noriaki Shimada, Masakiyo Hosokawa, Kan Chiba

Journal:

Year:

2003

Language:

english

File:

PDF, 199 KB

english, 2003

42

Cancer-type OATP1B3 mRNA has the potential to become a detection and prognostic biomarker for human colorectal cancer

Sun, Yuchen, Harada, Manami, Shimozato, Osamu, Souda, Hiroaki, Takiguchi, Nobuhiro, Nabeya, Yoshihiro, Kamijo, Takehiko, Akita, Hidetaka, Anzai, Naohiko, Chiba, Kan, Furihata, Tomomi

Journal:

Biomarkers in Medicine

Year:

2017

Language:

english

File:

PDF, 1.39 MB

english, 2017

43

Structural Organization and Characterization of the Regulatory Element of the Human Carboxylesterase (CES1A1 and CES1A2) genes

Hosokawa, Masakiyo, Furihata, Tomomi, Yaginuma, Yumiko, Yamamoto, Naoko, Watanabe, Natsuko, Tsukada, Eiko, Ohhata, Yoshiko, Kobayashi, Kaoru, Satoh, Testuo, Chiba, Kan

Journal:

Drug Metabolism and Pharmacokinetics

Year:

2008

Language:

english

File:

PDF, 973 KB

english, 2008

44

Melnick-Needles syndrome associated molecule, Filamin-A regulates dental epithelial cell migration and root formation

Hino, Ryoko, Yamada, Aya, Chiba, Yuta, Yoshizaki, Keigo, Fukumoto, Emiko, Iwamoto, Tsutomu, Maruya, Yuriko, Otsu, Keishi, Harada, Hidemistu, Saito, Kan, Fukumoto, Satoshi

Journal:

Pediatric Dental Journal

Year:

2020

File:

PDF, 2.13 MB

2020

45

Phenytoin-Allopurinol Interaction

Yokochi, Kenji, Yokochi, Akiko, Chiba, Kan, Ishizaki, Takashi

Journal:

Therapeutic Drug Monitoring

Year:

1982

File:

PDF, 404 KB

1982

46

Genetic Polymorphism of the CYP2C subfamily.

Journal:

Folia Pharmacologica Japonica

Year:

1998

File:

PDF, 7.38 MB

1998

47

Increased Expression of Drug-metabolizing Enzymes in Human Hepatocarcinoma FLC-4 Cells Cultured on Micro-space Cell Culture Plates

Kobayashi, Kaoru, Yoshida, Akane, Ejiri, Yoko, Takagi, Sachiko, Mimura, Hanaka, Hosoda, Masaya, Matsuura, Tomokazu, Chiba, Kan

Journal:

Drug Metabolism and Pharmacokinetics

Year:

2012

Language:

english

File:

PDF, 1.22 MB

english, 2012

48

Identification and function analysis of ameloblast differentiation-related molecules using mouse incisors

Saito, Kan, Chiba, Yuta, Yamada, Aya, Fukumoto, Satoshi

Journal:

Pediatric Dental Journal

Year:

2020

File:

PDF, 1.82 MB

2020

49

Well-controlled proinflammatory cytokine responses of Peyer’s patch cells to probiotic Lactobacillus casei

Yukihide Chiba, Kan Shida, Satoru Nagata, Mariko Wada, Lei Bian, Chongxin Wang, Toshiaki Shimizu, Yuichiro Yamashiro, Junko Kiyoshima-Shibata, Msanobu Nanno, Koji Nomoto

Journal:

Year:

2010

Language:

english

File:

PDF, 567 KB

english, 2010

50

Association of increased type I collagen expression and relative stromal overgrowth in mouse epididymis neonatally exposed to diethylstilbestrol

Koji Yamazaki, Hideki Fukata, Tetsuya Adachi, Hitoshi Tainaka, Masao Kohda, Masashi Yamazaki, Kensuke Kojima, Kan Chiba, Chisato Mori, Masatoshi Komiyama

Journal:

Molecular Reproduction and Development

Year:

2005

Language:

english

File:

PDF, 302 KB

english, 2005

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